| May 21, 2022 | ||
| Genoa | 15:15 | Bologna |
| Atalanta | 18:45 | Empoli |
| Fiorentina | 18:45 | Juventus |
| Lazio | 18:45 | Verona |
| May 22, 2022 | ||
| Spezia | 10:30 | SSC Napoli |
| Inter Milan | 16:00 | Sampdoria |
| Sassuolo | 16:00 | AC Milan |
| Salernitana | 19:00 | Udinese |
| Venezia | 19:00 | Cagliari |
| May 21, 2022 | ||
| Genoa | 15:15 | Bologna |
| Atalanta | 18:45 | Empoli |
| Fiorentina | 18:45 | Juventus |
| Lazio | 18:45 | Verona |
| May 22, 2022 | ||
| Spezia | 10:30 | SSC Napoli |
| Inter Milan | 16:00 | Sampdoria |
| Sassuolo | 16:00 | AC Milan |
| Salernitana | 19:00 | Udinese |
| Venezia | 19:00 | Cagliari |