| May 21, 2022 | ||
| Valencia | 15:30 | Celta Vigo |
| May 22, 2022 | ||
| Elche | 15:30 | Getafe |
| Alaves | 18:00 | Cadiz |
| Granada | 18:00 | Espanyol |
| Osasuna | 18:00 | Mallorca |
| Barcelona | 20:00 | Villarreal |
| Real Sociedad | 20:00 | Atlético de Madrid |
| Sevilla | 20:00 | Athletic Bilbao |
| May 21, 2022 | ||
| Valencia | 15:30 | Celta Vigo |
| May 22, 2022 | ||
| Elche | 15:30 | Getafe |
| Alaves | 18:00 | Cadiz |
| Granada | 18:00 | Espanyol |
| Osasuna | 18:00 | Mallorca |
| Barcelona | 20:00 | Villarreal |
| Real Sociedad | 20:00 | Atlético de Madrid |
| Sevilla | 20:00 | Athletic Bilbao |